Mouse Anti-EBV early antigen Clone 1108-1 mAb

1108-1 recognizes a 55, 50 kilodalton polypeptide associated with the early antigen of Epstein-Barr virus (EBV). p55 has been shown to be a phosphoprotein and p55, 50 has strong DNA-binding activity preferentially to single-stranded DNA. The Epstein-Barr virus is the causitive agent of infectious mononucleosis and is associated with two human neoplasms, Burkitt's lymphoma and nasopharyngeal carcinoma. Several EBV-related antigens associated with early or late functions of the viral genome have been identified. The early antigen may be virally or chemically induced in EBV infected cells and is the first detectable marker of EBV infection in human cells. For use with paraformaldehyde/acetone fixed cell preparations. Chemically induced Raji cells may be used as a positive control.