Comparison

Mouse Anti-Human Mannose Receptor Clone 15-2 mAb

Item no. CS-MON2073
Manufacturer Cell Sciences
Amount 100 ug
Category
Type Antibody Monoclonal
Applications FC
Specific against Human
Isotype IgG1
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Similar products CD206, CLEC13D, MMR, mannose receptor C type 1, OTTHUMP00000019245, OTTHUMP00000045206, macrophage mannose receptor
Available
Description
The Mannose Receptor (MR), a member of the vertebrate C-type lectin family, is a pattern recognition receptor that is involved in both innate and adaptive immunity. The 180 kDa transmembrane protein consists of 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail.The structure is shared by the family of multi lectin mannose receptors: the phospholipase A2-receptor, DEC 205 and the novel C-type lectin receptor (mannose receptor X). The MR recognizes a wide range of gram positive and gram negative bacteria, yeasts, parasites and mycobacteria. The MR has also been shown to bind and internalize tissue-type plasminogen activator. MR’s are present on monocytes and dendritic cells (DC) and are presumed to play a role in innate and adaptive immunity, the latter via processing by DC. The expression of MR as observed in immunohistology is present on tissue macrophages, dendritic cells, a subpopulation of endothelial cells, Kupffer cells and sperm cells. The expression of MR on monocytes increases during culture and can be enhanced by cytokines as IFN-gamma. Labeling of MR expressing monocytes/macrophages increases at 37C with prolonged incubation time probably due to internalization of the MR-antibody-complex. The antibody prevents binding of glycoproteins including t-PA to MR.Detection of the MR with anti-MR monoclonal antibody can substitute staining for mannose containing probes as labeled mannosylated BSA, a technique which is more cumbersome and less specific. Immunoglobulin type:Mouse IgG1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ug
Available: In stock
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