Rabbit Anti-Human GSK3 beta Clone Poly6042 Affinity Purified pAb

GSK-3a (glycogen synthase kinase-3 beta) is a 49 kD serine/threonine kinase that is a member of the CDC2/CDKX subfamily. This protein is expressed in the testis, thymus, prostate, and ovary, with weak expression in lung, brain, and kidney. GSK-3a is thought to participate in the insulin and Wnt signaling pathway and has been shown to phosphorylate c-jun to reduce DNA binding. GSK-3a can be modified by AKT phosphorylation which inhibits function. This protein has been shown to interact with axin and GBP/FRAT. The Poly6042 antibody recognizes human and mouse GSK-3a and is cross-reactive with GSK-3a. The Poly6042 antibody has been shown to be useful for Western blot.

Recombinant (partial), C-terminal

Upon receipt, store frozen at -20C C. Avoid repeated freeze-thaw cycles.