Goat Anti-Human TLR1 Affinity Purified pAb

Goat Anti-human TLR1 Affinity Purified monoclonal antibody. The TLR (toll-like receptors) family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transduction. TLR1, as well as the other TLR family members, are type I transmembrane receptors that characteristically contain an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride (LPS) stimulation, which results in the activation and translocation of NFeB and suggests that these receptors are involved in mediating inflammatory responses. Expression of TLR receptors is highest in peripheral blood leukocytes, macrophages, and monocytes. TLR6 is highly homologous to TLR1, sharing greater than 65% sequence identity, and, like other members of the TLR family, it induces NFeB signaling upon activation.

Recombinant human TLR1

Store at -20C. For long term storage, aliquot and store at -80C. Avoid repeated freeze-thaw cycles .