Rabbit Anti-Human MAP3K14/NIK pAb

Store at 2-4C for short term storage or at -20C in small aliquots for long term storage. Avoid repeated freeze-thaw cycles.

Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14), also known as NF-kappa B-Inducing Kinase (NIK), is a member of the MAP kinase kinase kinase family that binds TNF Receptor Associated Factor 2 (TRAF2) and stimulates NF-kappa B activity. NIK was initially isolated from a Human B cell cDNA library. NIK is a serine/threonine kinase and its kinase activity contributes to I-kappa B phosphorylation. The C-Terminal segment of NIK binds TRAF2. A mutant NIK with intact C-Terminus but without the two lysine residues at its catalytic domain serves as a dominant-negative inhibitor for NF-kappa B activation. NIK also interacts with TNF Receptor Associated Factor 6 (TRAF6) and mediates IL1-induced NF-kappa B activation.

E. coli, -expressed Recombinant Human NIK fragment (aa 795-947)

Centrifuge vial prior to opening. Reconstitute to 1 mg/ml by adding 200 ul of distilled water.