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Mouse Anti-Human CASP8 Active Clone C502S Affinity Purified mAb

Mouse Anti-Human CASP8 Active Clone C502S Affinity Purified mAb

Item no.	CS-CMC435
Manufacturer	Cell Sciences
Amount	100 ug
Category	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Cell Biology Cell Status Apoptosis Western Blot Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies
Type	Antibody Monoclonal
Applications	WB
Clone	C502S
Specific against	Human
Host	Mouse
Isotype	IgG1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Similar products	MCH5, CAP4, FLICE, MACH, apoptosis-related cysteine protease, ALPS2B, FLJ17672, MGC78473, FADD-homologous ICE/CED-3-like protease, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, OTTHUMP00000163720, caspase 8, caspase 8, cysteine protease, Mch5 isoform alpha, OTTHUMP00000163718, OTTHUMP00000163719, procaspase-8
Available
Description	Mouse Anti-Human Active Caspase 8 Clone C502S Affinity Purified monoclonal antibody. Caspase 8, a member of the caspase-family of proteases, plays a key role in mediating Fas (CD95) and TNF induced apoptosis. Caspase 8 is synthesized as inactive pro-enzyme. Activation of the enzyme involves proteolytic cleavage that leads to the release of the active p18 and p10 subunits. Activated caspase 8 is able to cleave and activate downstream caspases, such as caspase 3, -6, -7 and a death agonist member of the BCL2/BCL-xL family, Bid, leading to apoptosis.
Formulation	Liquid in PBS + 50% glycerol + 1% BSA + 0.02% thimerosal. Precaution: Thimerosal is a poisonous and hazardous substance which should be handled by trained staff only.
Purification	Biospecific affinity chromatography
Storage and Stability	Store at -20C or in working aliquots at -80C for long term storage. Avoid repeated freeze-thaw cycles .
Specificity	Detects the 10 kDa small subunit of human Caspase 8. Does not detect the full length Caspase 8.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

CS-CMC435.pdf

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Amount: 100 ug

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Delivery expected until 11/1/2024

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