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DNMT3L DNA Cytosine-5--Methyltransferase 3-Like Human Recombinant Protein

DNMT3L DNA Cytosine-5--Methyltransferase 3-Like Human Recombinant Protein

Item no.	BOS-PROTQ9UJW3
Manufacturer	Boster
Amount	10ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Solution
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	DNA (cytosine-5)-methyltransferase 3-like;DNMT3L;
Available
Contents	The DNMT3L solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Description	DNMT3L Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 411 amino acids (1-386) and having a molecular mass of 46.2kDa. DNMT3L is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Gene name	DNMT3L
Protein function	Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3.
Purification	Greater than 90.0% as determined by SDS-PAGE.
Shipping	Shipped with wet ice
Short description	DNMT3L Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 4146.2kDa. DNMT3L is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Storage	Store in -20° C for long term storage. After reconstitution, store in 4° C for short term usage within a few days. Avoid freeze-thaw cycles.
Subcellular localization	Nucleus
Tissue specificity	Expressed at low levels in several tissues including testis, ovary, and thymus.
Format Information	Sterile Filtered clear solution.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10ug

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Delivery expected until 10/4/2024

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