Item no. |
BOS-PROTQ9QYY1 |
Manufacturer |
Boster
|
Amount |
5ug |
Category |
|
Type |
Proteins |
Specific against |
other |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Interleukin-36 receptor antagonist protein;IL-36Ra ;Interleukin-1 HY1;IL-1HY1;Interleukin-1 delta;IL-1 delta;Interleukin-1 family member 5;IL-1F5;Interleukin-1 homolog 3;IL-1H3;Interleukin-1-like protein 1;IL-1L1;IL36RN;Fil1d, Il1f5, Il1h3, Il1hy1; FIL1 delta, IL-1F5, IL-1HY1, IL-1L1, IL-1RP3, IL-1ra Homolog 1, IL-1, delta |
Available |
|
Contents |
Protein concentration verified by UV Spectroscopy and/or SDS-PAGE gel. |
Description |
The IL-1 family is comprised of 11 structurally related ligands, including the recently re-named IL-36RA (IL-1F5), IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9). The interaction of IL-36 ligands with the IL-1Rrp2 receptor (IL-1R6) can induce various activities, including dendritic cell maturation and activation. IL-36RA can antagonize the NF-kappaB signaling induced by either IL-36α , -β or -γ by binding to the IL-1Rrp2 receptor in a manner that prevents the initiation of functional signaling. Recombinant human IL-36RA is an E. coli derived 17 kDa protein containing 154 amino acid residues. |
Gene full name |
Interleukin-36 receptor antagonist protein |
Gene name |
IL36RN |
Protein function |
Inhibits the activity of interleukin-36 (IL36A, IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti- inflammatory signaling pathway by recruiting SIGIRR. . |
Short description |
The IL-1 family is comprised of 11 structurally related ligands, including the recently re-named IL-36RA (IL-1F5), IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9). The interaction of IL-36 ligands with the IL-1Rrp2 receptor (IL-1R6) can induce various activities, including dendritic cell maturation and activation. IL-36RA can antagonize the NF-kappaB signaling induced by either IL-36α , -β or -γ by binding to the IL-1Rrp2 receptor in a manner that prevents the initiation of functional signaling. Recombinant human IL-36RA is an E. coli derived 17 kDa protein containing 154 amino acid residues. |
Storage |
Store in -20C for long term storage. After reconstitution, store in 4C for short term usage within a few days. Avoid freeze-thaw cycles. |
Subcellular localization |
Secreted . |
Tissue specificity |
Highly abundant in embryonic tissue and tissues containing epithelial cells. |
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