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Recombinant Human IL-36RA Protein

Recombinant Human IL-36RA Protein

Item no.	BOS-PROTQ9QYY1
Manufacturer	Boster
Amount	5ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Interleukin-36 receptor antagonist protein;IL-36Ra ;Interleukin-1 HY1;IL-1HY1;Interleukin-1 delta;IL-1 delta;Interleukin-1 family member 5;IL-1F5;Interleukin-1 homolog 3;IL-1H3;Interleukin-1-like protein 1;IL-1L1;IL36RN;Fil1d, Il1f5, Il1h3, Il1hy1; FIL1 delta, IL-1F5, IL-1HY1, IL-1L1, IL-1RP3, IL-1ra Homolog 1, IL-1, delta
Available
Contents	Protein concentration verified by UV Spectroscopy and/or SDS-PAGE gel.
Description	The IL-1 family is comprised of 11 structurally related ligands, including the recently re-named IL-36RA (IL-1F5), IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9). The interaction of IL-36 ligands with the IL-1Rrp2 receptor (IL-1R6) can induce various activities, including dendritic cell maturation and activation. IL-36RA can antagonize the NF-kappaB signaling induced by either IL-36α , -β or -γ by binding to the IL-1Rrp2 receptor in a manner that prevents the initiation of functional signaling. Recombinant human IL-36RA is an E. coli derived 17 kDa protein containing 154 amino acid residues.
Gene full name	Interleukin-36 receptor antagonist protein
Gene name	IL36RN
Protein function	Inhibits the activity of interleukin-36 (IL36A, IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti- inflammatory signaling pathway by recruiting SIGIRR. .
Short description	The IL-1 family is comprised of 11 structurally related ligands, including the recently re-named IL-36RA (IL-1F5), IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9). The interaction of IL-36 ligands with the IL-1Rrp2 receptor (IL-1R6) can induce various activities, including dendritic cell maturation and activation. IL-36RA can antagonize the NF-kappaB signaling induced by either IL-36α , -β or -γ by binding to the IL-1Rrp2 receptor in a manner that prevents the initiation of functional signaling. Recombinant human IL-36RA is an E. coli derived 17 kDa protein containing 154 amino acid residues.
Storage	Store in -20C for long term storage. After reconstitution, store in 4C for short term usage within a few days. Avoid freeze-thaw cycles.
Subcellular localization	Secreted .
Tissue specificity	Highly abundant in embryonic tissue and tissues containing epithelial cells.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5ug

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Delivery expected until 10/4/2024

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