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Human PLA2G2A ELISA Kit PicoKine®

Human PLA2G2A ELISA Kit PicoKine®

Item no.	BOS-EK1944
Manufacturer	Boster
Amount	96 wells/kit, with removable strips.
Category	Metabolism Cholesterol & Lipid Metabolism ELISA Enzymes Fatty Acid Catabolism ELISA & Immunoassays ELISA Kits Immunoassay
Type	Elisa-Kit
Applications	ELISA
Specific against	Human
Sensitivity	<50 pg/ml
ECLASS 10.1	32160605
ECLASS 11.0	32160605
UNSPSC	41116126
Alias	Phospholipase A2, membrane associated; GIIC sPLA2; Group IIA phospholipase A2; Non-pancreatic secretory phospholipase A2; NPS-PLA2; Phosphatidylcholine 2-acylhydrolase 2A; PLA2G2A; PLA2B; PLA2L; RASF-A
Available
Specificity	Natural and recombinant human PLA2G2A
Manufacturers Product Category	PicoKine® ELISA Kits
Manufacturers Research Category	Cancer, Cardiovascular, Lipases, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipid Signaling, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction, Signaling Pathway
Short Description	Human PLA2G2A ELISA Kit PicoKine® (96 Tests). Quantitate Human PLA2G2A in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 50pg/ml.
Description	Human PLA2G2A ELISA Kit PicoKine® (96 Tests). Quantitate Human PLA2G2A in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 50pg/ml.
Background	Phospholipase A2, membrane associated is an enzyme that in humans is encoded by the PLA2G2A gene. It is mapped to 1p36.13. The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5'UTRs have been found for this gene.
Gene Name	PLA2G2A
Application Details	Dilution ratio of 1:1, concentration in serum and plasma is around 6 ng/ml.
Immunogen	Expression system for standard: NS0; Immunogen sequence: N21-C144
Cross-reactivity	There is no detectable cross-reactivity with other relevant proteins.
Sample Type	cell culture supernatants, serum and plasma (heparin, EDTA).
Capture antibody\|Detection antibody	A monoclonal antibody from mouse\|a biotinylated detection polyclonal antibody from goat
Storage	Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
Anticoagulant	heparin or EDTA
Gene Full Name	phospholipase A2 group IIA
Protein Function	Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site which is distinct from the classical ligand-binding site and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferation in an integrin-dependent manner.
Subcellular Localization	Secreted, Cell membrane, Peripheral membrane protein

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