Item no. |
BOS-EK0449 |
Manufacturer |
Boster
|
Amount |
96 wells/kit, with removable strips. |
Category |
|
Type |
Elisa-Kit |
Applications |
ELISA |
Specific against |
Mouse |
Sensitivity |
<10 pg/ml |
ECLASS 10.1 |
32160605 |
ECLASS 11.0 |
32160605 |
UNSPSC |
41116126 |
Alias |
C-C motif chemokine 3;Heparin-binding chemotaxis protein;L2G25B;Macrophage inflammatory protein 1-alpha;MIP-1-alpha;SIS-alpha;Small-inducible cytokine A3;TY-5;Ccl3;Mip1a, Scya3; |
Available |
|
Manufacturers Product Category |
PicoKine® ELISA Kits |
Manufacturers Research Category |
Antiviral Signaling, Chemokines, Immune System Diseases, Immunology, Innate Immunity, Macrophage/Inflammation |
Short Description |
Mouse MIP-1Alpha/CCL3 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Ccl3 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 10pg/ml. |
Description |
Mouse MIP-1Alpha/CCL3 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Ccl3 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 10pg/ml. |
Background |
Chemokine (C-C motif) ligand 3 (CCL3), so known as Macrophage inflammatory protein-1alpha (MIP-1 alpha), is a protein that in humans is encoded by the CCL3 gene. It is a cytokine which belongs to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes. This gene is mapped to 17q12. CCL3 plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. It has been found that the activation of CCR5 by CCL3 directly and independently activates a G-protein signaling pathway through GNAI2 and a tyrosine phosphorylation signaling pathway through JAK2. |
Gene Name |
CCL3 |
Application Details |
Dilution ratio of 1:1, concentration in serum and plasma is around 50 pg/ml. |
Immunogen |
Expression system for standard: E.coli; Immunogen sequence: A24-A92 |
Cross-reactivity |
There is no detectable cross-reactivity with other relevant proteins. |
Sample Type |
cell culture supernatants, serum and plasma (heparin, EDTA, citrate). |
Capture antibody|Detection antibody |
monoclonal antibody from rat|polyclonal antibody from goat |
Storage |
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.) |
Anticoagulant |
heparin, EDTA or citrate |
Gene Full Name |
C-C motif chemokine 3 |
Molecular Weight |
10345 MW |
Protein Function |
Monokine with inflammatory, pyrogenic and chemokinetic properties. Has a potent chemotactic activity for eosinophils. Binding to a high-affinity receptor activates calcium release in neutrophils. |
Subcellular Localization |
Secreted. |
Tissue Specificity |
Expressed in lung, spleen, and pancreas. |
Protein Name |
C-C motif chemokine 3 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.