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Human PD-L2/B7-DC ELISA Kit PicoKine®

Human PD-L2/B7-DC ELISA Kit PicoKine®

Item no.	BOS-EK1447
Manufacturer	Boster
Amount	96 wells/kit, with removable strips.
Category	Oncology Metabolism Cholesterol & Lipid Metabolism By Cell Type Blastoma Carcinoma ELISA ELISA & Immunoassays ELISA Kits Immunoassay By Organ Lung Cancer
Type	Elisa-Kit
Applications	ELISA
Specific against	Human
Sensitivity	<12 pg/ml
ECLASS 10.1	32160605
ECLASS 11.0	32160605
UNSPSC	41116126
Alias	Programmed cell death 1 ligand 2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; Programmed death ligand 2; Butyrophilin B7-DC; B7-DC; CD273; PDCD1LG2; B7DC, CD273, PDCD1L2, PDL2;
Available
Manufacturers Product Category	PicoKine® ELISA Kits
Manufacturers Research Category	Immunoglobulins, Immunology, Receptors
Short Description	Human PD-L2/B7-DC ELISA Kit PicoKine® (96 Tests). Quantitate Human PDCD1LG2 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 12pg/ml.
Description	Human PD-L2/B7-DC ELISA Kit PicoKine® (96 Tests). Quantitate Human PDCD1LG2 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 12pg/ml.
Background	Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene. It is mapped to chromosome 9p24.2. PD-L2 is one of two ligands for programmed death-1 (PD-1), a member of the CD28 family of immuno-receptors. Northern blot analysis detect wide expression of PDL2, with highest levels in placenta, heart, pancreas, lung, and liver, and lower levels in spleen, lymph nodes, and thymus. PDL2 negatively regulates T cells and plays an essential role in immune tolerance.
Gene Name	PDCD1LG2
Immunogen	Expression system for standard: NS0; Immunogen sequence: L20-T220
Cross-reactivity	There is no detectable cross-reactivity with other relevant proteins.
Sample Type	cell culture supernatants, serum and plasma (heparin, EDTA).
Capture antibody\|Detection antibody	a monoclonal antibody from mouse\|a biotinylated polyclonal antibody from goat
Storage	Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
Anticoagulant	heparin or EDTA
Gene Full Name	programmed cell death 1 ligand 2
Protein Function	Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity)..
Subcellular Localization	Isoform 3: Secreted
Tissue Specificity	Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.

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