Item no. |
BOS-EK1447 |
Manufacturer |
Boster
|
Amount |
96 wells/kit, with removable strips. |
Category |
|
Type |
Elisa-Kit |
Applications |
ELISA |
Specific against |
Human |
Sensitivity |
<12 pg/ml |
ECLASS 10.1 |
32160605 |
ECLASS 11.0 |
32160605 |
UNSPSC |
41116126 |
Alias |
Programmed cell death 1 ligand 2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; Programmed death ligand 2; Butyrophilin B7-DC; B7-DC; CD273; PDCD1LG2; B7DC, CD273, PDCD1L2, PDL2; |
Available |
|
Manufacturers Product Category |
PicoKine® ELISA Kits |
Manufacturers Research Category |
Immunoglobulins, Immunology, Receptors |
Short Description |
Human PD-L2/B7-DC ELISA Kit PicoKine® (96 Tests). Quantitate Human PDCD1LG2 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 12pg/ml. |
Description |
Human PD-L2/B7-DC ELISA Kit PicoKine® (96 Tests). Quantitate Human PDCD1LG2 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 12pg/ml. |
Background |
Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene. It is mapped to chromosome 9p24.2. PD-L2 is one of two ligands for programmed death-1 (PD-1), a member of the CD28 family of immuno-receptors. Northern blot analysis detect wide expression of PDL2, with highest levels in placenta, heart, pancreas, lung, and liver, and lower levels in spleen, lymph nodes, and thymus. PDL2 negatively regulates T cells and plays an essential role in immune tolerance. |
Gene Name |
PDCD1LG2 |
Immunogen |
Expression system for standard: NS0; Immunogen sequence: L20-T220 |
Cross-reactivity |
There is no detectable cross-reactivity with other relevant proteins. |
Sample Type |
cell culture supernatants, serum and plasma (heparin, EDTA). |
Capture antibody|Detection antibody |
a monoclonal antibody from mouse|a biotinylated polyclonal antibody from goat |
Storage |
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.) |
Anticoagulant |
heparin or EDTA |
Gene Full Name |
programmed cell death 1 ligand 2 |
Protein Function |
Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).. |
Subcellular Localization |
Isoform 3: Secreted |
Tissue Specificity |
Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.