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Anti-Phospho-AMPA Receptor (GluR 1) (Ser845) GRIA1 Rabbit Monoclonal Antibody, Clone#RM296

Anti-Phospho-AMPA Receptor (GluR 1) (Ser845) GRIA1 Rabbit Monoclonal Antibody, Clone#RM296

Item no.	BOS-P02677-2
Manufacturer	Boster
Amount	100ul
Category	Food Safety Allergenes Neuroscience Molecular Targets for Neuroscience Neural Signaling Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody
Format	Liquid
Applications	WB, IHC
Clone	RM296
Specific against	Human
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Glutamate receptor 1;GluR-1;AMPA-selective glutamate receptor 1;GluR-A;GluR-K1;Glutamate receptor ionotropic, AMPA 1;GluA1;GRIA1;GLUH1, GLUR1;
Available
Manufacturers Product Category	Primary Antibodies, Monoclonal Antibodies
Manufacturers Research Category	Ligand-Gated Ion Channels, Neuroscience, Neurotransmission, Receptors / Channels
Short Description	Boster Bio Anti-Phospho-AMPA Receptor (GluR 1) (Ser845) GRIA1 Rabbit Monoclonal Antibody, Clone#RM296 (Catalog # P02677-2). Tested in IHC, WB applications. This antibody reacts with Human.
Description	Boster Bio Anti-Phospho-AMPA Receptor (GluR 1) (Ser845) GRIA1 Rabbit Monoclonal Antibody, Clone#RM296 (Catalog # P02677-2). Tested in IHC, WB applications. This antibody reacts with Human.
Gene Name	GRIA1
Clonality	Monoclonal
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Contents	50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Predicted Reactivity	Mouse, Rat
Application Details	Immunohistochemistry (IHC): 1:500-1:1000 dilution WB: 1:1000-1:2000 dilution.
Immunogen	A phospho-peptide corresponding to human Phospho-Glutamate Receptor 1 (GluR1) (Ser845)
Cross-reactivity	Reacts to human GluR1 AMPA Receptor only when phosphorylated at Ser845. No cross-reactivity to GluR1 that is not phosphorylated at Ser845. May also react to mouse or rat Phospho-AMPA Receptor (GluR1) (Ser845) as predicted by immunogen homology.
Purification	Protein A affinity purified from an animal origin-free culture supernatant
Storage	Store at -20°C for one year. Avoid repeated freeze-thaw cycles.
Gene Full Name	Glutamate receptor 1
Molecular Weight	101506 MW
Protein Function	Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Subcellular Localization	Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine. Early endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. Colocalizes with PDLIM4 in early endosomes. Displays a somatodendritic localization and is excluded from axons in neurons (By similarity).
Tissue Specificity	Widely expressed in brain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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