Item no. |
BOS-P02677-2 |
Manufacturer |
Boster
|
Amount |
100ul |
Category |
|
Type |
Antibody |
Format |
Liquid |
Applications |
WB, IHC |
Clone |
RM296 |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Glutamate receptor 1;GluR-1;AMPA-selective glutamate receptor 1;GluR-A;GluR-K1;Glutamate receptor ionotropic, AMPA 1;GluA1;GRIA1;GLUH1, GLUR1; |
Available |
|
Manufacturers Product Category |
Primary Antibodies, Monoclonal Antibodies |
Manufacturers Research Category |
Ligand-Gated Ion Channels, Neuroscience, Neurotransmission, Receptors / Channels |
Short Description |
Boster Bio Anti-Phospho-AMPA Receptor (GluR 1) (Ser845) GRIA1 Rabbit Monoclonal Antibody, Clone#RM296 (Catalog # P02677-2). Tested in IHC, WB applications. This antibody reacts with Human. |
Description |
Boster Bio Anti-Phospho-AMPA Receptor (GluR 1) (Ser845) GRIA1 Rabbit Monoclonal Antibody, Clone#RM296 (Catalog # P02677-2). Tested in IHC, WB applications. This antibody reacts with Human. |
Gene Name |
GRIA1 |
Clonality |
Monoclonal |
Concentration |
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
Contents |
50% Glycerol/PBS with 1% BSA and 0.09% sodium azide |
Predicted Reactivity |
Mouse, Rat |
Application Details |
Immunohistochemistry (IHC): 1:500-1:1000 dilution
WB: 1:1000-1:2000 dilution. |
Immunogen |
A phospho-peptide corresponding to human Phospho-Glutamate Receptor 1 (GluR1) (Ser845) |
Cross-reactivity |
Reacts to human GluR1 AMPA Receptor only when phosphorylated at Ser845. No cross-reactivity to GluR1 that is not phosphorylated at Ser845. May also react to mouse or rat Phospho-AMPA Receptor (GluR1) (Ser845) as predicted by immunogen homology. |
Purification |
Protein A affinity purified from an animal origin-free culture supernatant |
Storage |
Store at -20°C for one year. Avoid repeated freeze-thaw cycles. |
Gene Full Name |
Glutamate receptor 1 |
Molecular Weight |
101506 MW |
Protein Function |
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. |
Subcellular Localization |
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine. Early endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. Colocalizes with PDLIM4 in early endosomes. Displays a somatodendritic localization and is excluded from axons in neurons (By similarity). |
Tissue Specificity |
Widely expressed in brain. |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.