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Anti-Caspase-3 Rabbit Monoclonal Antibody, Clone#RM250

Anti-Caspase-3 Rabbit Monoclonal Antibody, Clone#RM250

Item no.	BOS-M00334-8
Manufacturer	Boster
Amount	100 ul
Category	Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Antibodies Cell Biology Cell Status Apoptosis Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Primary
Format	Liquid
Applications	WB, IHC
Clone	RM250
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Caspase-3;CASP-3;3.4.22.56;Apopain;Cysteine protease CPP32;CPP-32;Protein Yama;SREBP cleavage activity 1;SCA-1;Caspase-3 subunit p17;Caspase-3 subunit p12;CASP3;CPP32;
Available
Manufacturer - Category	Primary Antibodies, Monoclonal Antibodies, Rabbit Monoclonal Antibodies, 2279
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	31608 MW
Clonality	Monoclonal
Application Details	Immunohistochemistry (IHC): 1:1000-1:2500 dilution WB: 1:1000-1:2000 dilution.
Manufacturer - Gene Name	CASP3
Gene Full Name	Caspase-3
Immunogen	A synthetic peptide corresponding to residues within human Caspase-3 subunit p17
Contents	50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification	Protein A affinity purified from an animal origin-free culture supernatant
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Manufacturer - Research Category	Alzheimer's Disease, Apoptosis, Apoptotic Markers, Cancer, Caspases, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Neurodegenerative Disease, Neurology Process, Neuroscience
Protein Function	Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Subcellular Localization	Cytoplasm.
Short Description	Boster Bio Anti-Caspase-3 Rabbit Monoclonal Antibody, Clone#RM250 (Catalog # M00334-8). Tested in IHC, WB applications. This antibody reacts with Human.
Description	Boster Bio Anti-Caspase-3 Rabbit Monoclonal Antibody, Clone#RM250 (Catalog # M00334-8). Tested in IHC, WB applications. This antibody reacts with Human.
Tissue Specificity	Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 5/1/2025

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