Item no. |
BOS-A11201 |
Manufacturer |
Boster
|
Amount |
100ul |
Category |
|
Type |
Antibody |
Format |
Liquid |
Applications |
WB |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Available |
|
Manufacturers Product Category |
Primary Antibodies |
Manufacturers Research Category |
Cell Type Marker, Neuron Marker, Neuroscience, Neurotransmission, Secretory Vesicles, Synapse Marker |
Short Description |
Boster Bio Anti-synaptophysin 2 Synpr Antibody (Catalog # A11201). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. |
Description |
Boster Bio Anti-synaptophysin 2 Synpr Antibody (Catalog # A11201). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. |
Background |
Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms, and thus can be used as a marker in tumor diagnosis (1). Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore (2). Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases (3). Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex (4).
Wiedenmann, B. et al. (1986) Proc Natl Acad Sci USA 83, 3500-4.
Valtorta, F. et al. (2004) Bioessays 26, 445-53.
Arthur, C.P. and Stowell, M.H. (2007) Structure 15, 707-14.
Bonanomi, D. et al. (2007) Biochem J 404, 525-34. |
Gene Name |
SYNPR |
Clonality |
Polyclonal |
Concentration |
1 mg/ml |
Contents |
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Application Details |
Predicted MW: 37kd
Western blotting: 1:500~1:1000 |
Immunogen |
Peptide sequence around aa.257~261(G-P-T-S-F)derived from Rat synaptophysin 2. |
Purification |
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
Storage |
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.