Anti-synaptophysin 2 Synpr Antibody

Primary Antibodies

Boster Bio Anti-synaptophysin 2 Synpr Antibody (Catalog # A11201). Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms, and thus can be used as a marker in tumor diagnosis (1). Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore (2). Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases (3). Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex (4).



Wiedenmann, B. et al. (1986) Proc Natl Acad Sci USA 83, 3500-4.

Valtorta, F. et al. (2004) Bioessays 26, 445-53.

Arthur, C.P. and Stowell, M.H. (2007) Structure 15, 707-14.

Bonanomi, D. et al. (2007) Biochem J 404, 525-34.

Polyclonal

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Peptide sequence around aa.257~261(G-P-T-S-F)derived from Rat synaptophysin 2.

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.