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Anti-Granzyme B/Gzmb Antibody Picoband™

Anti-Granzyme B/Gzmb Antibody Picoband™

Item no.	BOS-A00353-1
Manufacturer	Boster
Amount	100 ug/vial
Category	Antibodies Western Blot ELISA Primary Antibodies
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, ELISA
Specific against	Mouse, Rat
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Granzyme B (G,H); CTLA-1; Cytotoxic cell protease 1; CCP1; Fragmentin-2; Gzmb; Ctla-1; Ctla1
Available
Manufacturers Product Category	Primary Antibodies, Rabbit Polyclonal Antibodies
Manufacturers Research Category	Adaptive Immunity, Apoptosis, Cell Biology, Immunology, Innate Immunity, NK Cells, T Cells
Short Description	Boster Bio Anti-Granzyme B/Gzmb Antibody Picoband™ catalog # A00353-1. Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat.
Description	Boster Bio Anti-Granzyme B/Gzmb Antibody Picoband™ catalog # A00353-1. Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat.
Background	Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.
Gene Name	GZMB
Application Details	Western blot, 0.1-0.5μg/ml Direct ELISA, 0.1-0.5μg/ml
Clonality	Polyclonal
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Contents	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05mg NaN₃.
Immunogen	E. coli-derived mouse Granzyme B recombinant protein (Position: I21-S247).
Cross-reactivity	No cross-reactivity with other proteins.
Storage	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Gene Full Name	granzyme B
Molecular Weight	28 kDa
Protein Function	This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis (By similarity)..
Subcellular Localization	Cytoplasmic granule. Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug/vial

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Delivery expected until 9/13/2024

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