Item no. |
BOS-A00353-1 |
Manufacturer |
Boster
|
Amount |
100 ug/vial |
Category |
|
Type |
Antibody Polyclonal |
Format |
Lyophilized |
Applications |
WB, ELISA |
Specific against |
Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Granzyme B (G,H); CTLA-1; Cytotoxic cell protease 1; CCP1; Fragmentin-2; Gzmb; Ctla-1; Ctla1 |
Available |
|
Manufacturers Product Category |
Primary Antibodies, Rabbit Polyclonal Antibodies |
Manufacturers Research Category |
Adaptive Immunity, Apoptosis, Cell Biology, Immunology, Innate Immunity, NK Cells, T Cells |
Short Description |
Boster Bio Anti-Granzyme B/Gzmb Antibody Picoband™ catalog # A00353-1. Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. |
Description |
Boster Bio Anti-Granzyme B/Gzmb Antibody Picoband™ catalog # A00353-1. Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. |
Background |
Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. |
Gene Name |
GZMB |
Application Details |
Western blot, 0.1-0.5μg/ml Direct ELISA, 0.1-0.5μg/ml |
Clonality |
Polyclonal |
Concentration |
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml. |
Contents |
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. |
Immunogen |
E. coli-derived mouse Granzyme B recombinant protein (Position: I21-S247). |
Cross-reactivity |
No cross-reactivity with other proteins. |
Storage |
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles. |
Reconstitution |
Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Gene Full Name |
granzyme B |
Molecular Weight |
28 kDa |
Protein Function |
This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis (By similarity).. |
Subcellular Localization |
Cytoplasmic granule. Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.