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Anti-Islet 1/ISL1 Antibody Picoband™

Anti-Islet 1/ISL1 Antibody Picoband™

Item no.	BOS-A02969-1
Manufacturer	Boster
Amount	100 ug/vial
Category	Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, IHC
Specific against	Human, Rat
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Insulin gene enhancer protein ISL-1;Islet-1;ISL1;
Available
Manufacturers Product Category	Primary Antibodies, Rabbit Polyclonal Antibodies
Manufacturers Research Category	Atherosclerosis, Cardiogenesis, Cardiovascular, Cell Type Marker, Developmental Biology, Diabetes-associated, Intracellular, Lineage Markers, Lineage Specification, Neural Stem Cells, Neurogenesis, Neurology Process, Neuron Marker, Neuroscience, Organogenesis, Stem Cells, Transcription Factors/Regulators
Short Description	Boster Bio Anti-Islet 1/ISL1 Antibody Picoband™ catalog # A02969-1. Tested in IHC, WB applications. This antibody reacts with Human, Rat.
Description	Boster Bio Anti-Islet 1/ISL1 Antibody Picoband™ catalog # A02969-1. Tested in IHC, WB applications. This antibody reacts with Human, Rat.
Background	Insulin gene enhancer protein ISL-1 is a protein that in humans is encoded by the isl1 gene. This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
Gene Name	ISL1
Application Details	Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat Western blot, 0.1-0.5μg/ml, Human, Rat
Application Notes	Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
Clonality	Polyclonal
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Contents	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen	A synthetic peptide corresponding to a sequence in the middle region of human Islet 1, identical to the related mouse and rat sequences.
Purification	Immunogen affinity purified.
Cross-reactivity	No cross-reactivity with other proteins
Storage	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Gene Full Name	Insulin gene enhancer protein ISL-1
Molecular Weight	39036 MW
Protein Function	Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity)..
Subcellular Localization	Nucleus.
Tissue Specificity	Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.
Protein Name	Insulin gene enhancer protein ISL-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug/vial

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Delivery expected until 10/4/2024

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