Item no. |
BOS-PB9622 |
Manufacturer |
Boster
|
Amount |
100 ug/vial |
Category |
|
Type |
Antibody Polyclonal |
Format |
Lyophilized |
Applications |
WB |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Syncytin-1;Endogenous retrovirus group W member 1;Env-W;Envelope polyprotein gPr73;Enverin;HERV-7q Envelope protein;HERV-W envelope protein;HERV-W_7q21.2 provirus ancestral Env polyprotein;Syncytin;Surface protein;SU;gp50;Transmembrane protein;TM;gp24;ERVW-1;ERVWE1; |
Available |
|
Manufacturers Product Category |
Primary Antibodies, Rabbit Polyclonal Antibodies |
Manufacturers Research Category |
Developmental Biology, Reproduction |
Short Description |
Boster Bio Anti-ERVW-1 Antibody Picoband™ catalog # PB9622. Tested in WB applications. This antibody reacts with Human. |
Description |
Boster Bio Anti-ERVW-1 Antibody Picoband™ catalog # PB9622. Tested in WB applications. This antibody reacts with Human. |
Background |
ERVW-1 is also known as ERVWE1. The human ERVWE1 locus is derived from a human endogenous retrovirus-W (HERV-W) provirus located on chromosome 7. This provirus has inactivating mutations in the gag and pol genes, but the envelope glycoprotein gene has been selectively preserved. The product of this gene, syncytin, is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. |
Gene Name |
ERVW-1 |
Application Details |
Western blot, 0.1-0.5μg/ml, Human |
Application Notes |
Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users. |
Clonality |
Polyclonal |
Concentration |
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml. |
Contents |
Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3. |
Immunogen |
A synthetic peptide corresponding to a sequence at the C-terminus of human ERVW-1. |
Purification |
Immunogen affinity purified. |
Cross-reactivity |
No cross-reactivity with other proteins |
Storage |
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles. |
Reconstitution |
Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Gene Full Name |
Syncytin-1 |
Molecular Weight |
59866 MW |
Protein Function |
This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904).. |
Subcellular Localization |
Transmembrane protein: Cell membrane ; Single-pass type I membrane protein. |
Tissue Specificity |
Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia.. |
Protein Name |
Syncytin-1 |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.