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Anti-Glutathione Peroxidase 1/GPX1 Antibody Picoband™

Anti-Glutathione Peroxidase 1/GPX1 Antibody Picoband™

Item no.	BOS-PB9203
Manufacturer	Boster
Amount	100 ug/vial
Category	Oncology Metabolism Cholesterol & Lipid Metabolism Antibodies Cell Biology Cell Status Apoptosis Cell Metabolism Immunohistochemistry Western Blot Primary Antibodies By Organ Breast Cancer
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, IHC
Specific against	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Glutathione peroxidase 1;GPx-1;GSHPx-1;1.11.1.9;Cellular glutathione peroxidase;GPX1;
Similar products	AL033363 antibody, Cellular glutathione peroxidase antibody, Glutathione peroxidase 1 antibody, Glutathione peroxidase antibody, GPx 1 antibody, GPx-1 antibody, GPX1 antibody, GPX1_HUMAN antibody, GPXD antibody, GSHPx-1 antibody, GSHPX1 antibody, MGC14399 antibody, MGC88245 antibody
Available
Manufacturers Product Category	Primary Antibodies, Rabbit Polyclonal Antibodies
Manufacturers Research Category	Cancer, Cancer Metabolism, Cell Biology, Metabolism, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Oxidative Stress, Pathways and Processes, Redox Metabolism, Signal Transduction
Short Description	Boster Bio Anti-Glutathione Peroxidase 1/GPX1 Antibody Picoband™ catalog # PB9203. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-Glutathione Peroxidase 1/GPX1 Antibody Picoband™ catalog # PB9203. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Background	Glutathione peroxidase 1, also known as, GPX-1 is an enzyme that in humans is encoded by the GPX1 gene. It is mapped to 3p21.31. This gene encodes a member of the glutathione peroxidase family, consisting of eight known glutathione peroxidases (Gpx1-8) in humans. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. It has been reported that the protein encoded by this gene protects from CD95-induced apoptosis in cultured breast cancer cells and inhibits 5-lipoxygenase in blood cells, and its overexpression delays endothelial cell growth and increases resistance to toxic challenges. GPX1 is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA.
Gene Name	GPX1
Application Details	Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human, Rat, By Heat
Application Notes	WB: The detection limit for GPX1 is approximately 0.25ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
Clonality	Polyclonal
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Contents	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
Immunogen	A synthetic peptide corresponding to a sequence in the middle region of human GPX1, different from the related mouse sequence by six amino acids and from the related rat sequence by five amino acids.
Purification	Immunogen affinity purified.
Cross-reactivity	No cross-reactivity with other proteins
Storage	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Gene Full Name	Glutathione peroxidase 1
Molecular Weight	22088 MW
Protein Function	Protects the hemoglobin in erythrocytes from oxidative breakdown.
Subcellular Localization	Cytoplasm.
Protein Name	Glutathione peroxidase 1
Sequence Similarities	Belongs to the glutathione peroxidase family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.