Item no. |
BOS-PA1326 |
Manufacturer |
Boster
|
Amount |
100 ug/vial |
Category |
|
Type |
Antibody Polyclonal |
Format |
Lyophilized |
Applications |
WB |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Hematopoietically expressed homeobox antibody, Hematopoietically-expressed homeobox protein HHEX antibody, HEX antibody, HHEX antibody, HHEX_HUMAN antibody, HMPH antibody, Homeobox hematopoietically expressed antibody, Homeobox protein HEX antibody, Homeobox protein PRH antibody, HOX11L PEN antibody, PRH antibody, PRHX antibody, Proline rich homeodomain containing transcription factor antibody, OTTHUMP00000206478 antibody, OTTHUMP00000206479 antibody, OTTHUMP00000206480 antibody, OTTHUMP00000206482 antibody, OTTHUMP00000207360 antibody, USURPIN antibody, Usurpin beta antibody |
Similar products |
Hematopoietically expressed homeobox antibody, Hematopoietically-expressed homeobox protein HHEX antibody, HEX antibody, HHEX antibody, HHEX_HUMAN antibody, HMPH antibody, Homeobox hematopoietically expressed antibody, Homeobox protein HEX antibody, Homeobox protein PRH antibody, HOX11L PEN antibody, PRH antibody, PRHX antibody, Proline rich homeodomain containing transcription factor antibody, OTTHUMP00000206478 antibody, OTTHUMP00000206479 antibody, OTTHUMP00000206480 antibody, OTTHUMP00000206482 antibody, OTTHUMP00000207360 antibody, USURPIN antibody, Usurpin beta antibody |
Available |
|
Background |
Hematopoietically-expressed homeobox protein HHEX is a protein that in humans is encoded by the HHEX gene. Homeobox genes are members of a family of transcription factors that regulate tissue development in many different organisms. Hromas et al.(1993) set out to identify homeobox genes that might play a role in hematopoiesis. And using somatic cell hybrid analysis, they mapped the HHEX gene to chromosome 10, where the HOX11 gene is located. Homeobox genes are involved in neoplastic transformation of both epithelial and hemopoietic tissues. The divergent homeobox gene HEX is expressed in the anterior visceral endoderm during early mouse development and in some adult tissues of endodermal origin, including liver and thyroid. D'Elia et al.'s findings suggested that regulation of HEX entry in the nucleus of thyrocytes may represent a critical step during human thyroid tumorigenesis. |
Concentration |
Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Contents |
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
Cross reactivity |
No cross reactivity with other proteins |
Description |
Rabbit IgG polyclonal antibody for Hematopoietically-expressed homeobox protein HHEX(HHEX) detection. Tested with WB in Human; Mouse; Rat. |
Gene full name |
Hematopoietically-expressed homeobox protein HHEX |
Gene name |
HHEX |
Immunogen |
A synthetic peptide corresponding to a sequence at the N-terminus of human Hex(24-39aa QPAHPTPFYIEDILGR), different from the related mouse sequence by one amino acid. |
MW |
30022 MW |
Predicted reactivity |
Chicken |
Protein function |
Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). |
Protein name |
Hematopoietically-expressed homeobox protein Hhex(Homeobox protein HEX) |
Purification |
Immunogen affinity purified. |
Recommended detection ystems |
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot. |
Reconstitution |
Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Research category |
|epigenetics and nuclear signaling|transcription|domain families|developmental families| stem cells|lineage markers|mesoderm| developmental biology|embryogenesis|axis formation and symmetry|lineage specification |
Storage |
At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for a longer time.Avoid repeated freezing and thawing. |
Subcellular localization |
Nucleus . |
Tissue specificity |
Liver and promyelocytic leukemia cell line HL- 60. |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.