Item no. |
BOS-PA1542 |
Manufacturer |
Boster
|
Amount |
100 ug/vial |
Category |
|
Type |
Antibody Polyclonal |
Format |
Lyophilized |
Applications |
WB, IHC |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
AI047524 antibody, AI303044 antibody, Beta thionase antibody, Beta-thionase antibody, Cbs antibody, Cbs cystathionine beta-synthase antibody, CBS_HUMAN antibody, Cystathionine beta synthase antibody, Cystathionine beta-synthase antibody, EC 4.2.1.22 antibody, HIP 4 antibody, HIP4 antibody, Methylcysteine synthase antibody, MGC18856 antibody, MGC18895 antibody, MGC37300 antibody, OTTHUMP00000109416 antibody, OTTHUMP00000109418 antibody, Serine sulfhydrase antibody |
Similar products |
AI047524 antibody, AI303044 antibody, Beta thionase antibody, Beta-thionase antibody, Cbs antibody, Cbs cystathionine beta-synthase antibody, CBS_HUMAN antibody, Cystathionine beta synthase antibody, Cystathionine beta-synthase antibody, EC 4.2.1.22 antibody, HIP 4 antibody, HIP4 antibody, Methylcysteine synthase antibody, MGC18856 antibody, MGC18895 antibody, MGC37300 antibody, OTTHUMP00000109416 antibody, OTTHUMP00000109418 antibody, Serine sulfhydrase antibody |
Available |
|
Background |
CBS, Cystathionine Beta-Synthase, catalyzes the first irreversible step of transsulfuration. The CBS enzyme is a homotetramer of 63-kD subunits and requires pyridoxal phosphate and heme for activity. The CBS gene, which is mapped to chromosome 21q22, contains 23 exons, ranging in size from 42 to 299 bp. The human CBS protein can substitute for the endogenous yeast CBS protein in Saccharomyces cerevisiae. The catalytic domain of the CBS protein is located in the N-terminal 409 amino acids, and a regulatory domain is located in the C-terminal 142 amino acids.A mutation that deletes the C-terminal 145 amino acids of CBS could restore activity of several CBS mutant alleles found in homocystinurics. |
Concentration |
Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Contents |
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
Cross reactivity |
No cross reactivity with other proteins |
Description |
Rabbit IgG polyclonal antibody for Cystathionine beta-synthase(CBS) detection. Tested with WB, IHC-P in Human. |
Gene full name |
Cystathionine beta-synthase |
Gene name |
CBS |
Immunogen |
A synthetic peptide corresponding to a sequence in the middle region of human CBS(322-342aa KWFKSNDEEAFTFARMLIAQE). |
MW |
60587 MW |
Predicted reactivity |
Bovine |
Protein function |
Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity). |
Protein name |
Cystathionine beta-synthase |
Purification |
Immunogen affinity purified. |
Recommended detection ystems |
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P). |
Reconstitution |
Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Research category |
|signal transduction|metabolism|amino acids| cancer|cancer metabolism|cellular metabolic process| metabolism|pathways and processes|metabolic signaling pathways|amino acid metabolism|types of disease |
Sequence similarities |
Belongs to the cysteine synthase/cystathionine beta- synthase family. |
Storage |
At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for a longer time.Avoid repeated freezing and thawing. |
Subcellular localization |
Cytoplasm . Nucleus . |
Tissue specificity |
In the adult strongly expressed in liver and pancreas, some expression in heart and brain, weak expression in lung and kidney. In the fetus, expressed in brain, liver and kidney. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.