Anti-LST1 Purified Monoclonal Antibody

Primary Antibodies, Monoclonal Antibodies

Store at 2-8°C. Do not freeze.

Monoclonal

LST1

LST1 (leukocyte-specific transcript 1, also known as B144) is expressed in cells of myeloid/erythroid lineage (monocytes, granulocytes, dendritic cells, platelets, erythrocytes). At least 14 alternatively spliced variants (LST1/A –; LST1/N) can be detected; some of them (LST1/A, B, C, G, I, K) are transmembrane cell surface-exposed forms, the other are soluble. LST1 induces production of long, thin filopodia in dendritic cells, has an inhibitory effect on lymphocyte proliferation and may have an immunomodulatory role. LST1/A is an 11 kDa transmembrane adaptor present in membrane rafts and forms spontaneously covalent homodimers. Its intracellular domain contains two tyrosine motifs, one of them being an ITIM very similar to such motifs in Siglec.

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

1 mg/ml

Possible role in modulating immune responses. Induces
morphological changes including production of filopodia and
microspikes when overexpressed in a variety of cell types and may
be involved in dendritic cell maturation. Isoform 1 and isoform 2
have an inhibitory effect on lymphocyte proliferation.

Boster Bio Anti-LST1 Purified Monoclonal Antibody (Catalog# M03702). Tested in IP, WB, ICC application(s). This antibody reacts with Human.

Expressed in lung, tonsil, thymus, placenta,
kidney, fetal spleen, fetal liver and brain.