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Anti-human CD4 Monoclonal Antibody Unconjugated, Flow Validated

Anti-human CD4 Monoclonal Antibody Unconjugated, Flow Validated

Item no.	BOS-FC00344-100ug
Manufacturer	Boster
Amount	100ug
Format	Liquid
Applications	FC
Clone	OKT4
Specific against	Human, Monkey, Rhesus macaque
Host	Mouse
Isotype	IgG2b Kappa
Sensitivity	5ul per sample
Alias	T-cell surface glycoprotein CD4;T-cell surface antigen T4/Leu-3;CD4;CD4;
Available
Manufacturers Product Category	Primary Antibodies, Monoclonal Antibodies
Manufacturers Research Category	Adaptive Immunity, Antiviral Signaling, Hematopoietic Progenitors, Immune System Diseases, Immunology, Lymphoid, Myeloid, Stem Cells, T Cells, T Lymphocytic Lineage
Short Description	Boster Bio Anti-human CD4 Monoclonal Antibody Unconjugated, Flow Validated (Catalog# FC00344). Tested in Flow Cytometry application(s). This antibody reacts with Human, Rhesus monkey, Cynomolgus monkey.
Description	Boster Bio Anti-human CD4 Monoclonal Antibody Unconjugated, Flow Validated (Catalog# FC00344). Tested in Flow Cytometry application(s). This antibody reacts with Human, Rhesus monkey, Cynomolgus monkey.
Background	CD stands for "cluster of differentiation"; the number that follows is arbitrarily assigned. In the full designation the cell type and nature and molecular weight of the antigen are given in brackets; for CD4, this is as follows: [T, gp55]. CD4 is present on a subset of T lymphocytes ("helper/inducer" T cells) and is also expressed at a lower level on monocytes, tissue macrophages and granulocytes. The antigen is involved in binding to MHC class II molecules. The intracellular domain of the antigen is associated with p56lck protein tyrosine kinase.
Gene Name	CD4
Clonality	Monoclonal
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Contents	PBS pH 7.2, 0.1% (w/v) BSA, 0.09% (w/v) sodium azide
Application Details	User needs to optimize the dilution ratio for this antibody.
Immunogen	Human peripheral blood T lymphocytes
Purification	Protein A purified
Storage	Store at 2-8°C. Avoid repeated freeze-thaw cycles.
Gene Full Name	T-cell surface glycoprotein CD4
Molecular Weight	51111 MW
Protein Function	Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Subcellular Localization	Cell membrane; Single-pass type I membrane protein. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Protein Name	T-cell surface glycoprotein CD4

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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