NR1I2 polyclonal antibody

O75469

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

NR1I2 pAb detects endogenous levels of NR1I2 protein.

ca. 50 kDa

BXR, Nr1i2, NR1I2_HUMAN, Nuclear receptor subfamily 1 group I member 2, ONR 1, ONR1, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PAR1, Orphan nuclear receptor PXR, PAR 1, PAR 2, PAR, PAR q, PAR1, PAR2, PARq, pregnane X nuclear receptor variant 2, Pregnane X receptor, PRR, PXR, SAR, Steroid and xenobiotic receptor, SXR