Item no. |
BS7284-100 |
Manufacturer |
Bioworld Technology, Inc
|
Amount |
100ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
BXR, Nr1i2, NR1I2_HUMAN, Nuclear receptor subfamily 1 group I member 2, ONR 1, ONR1, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PAR1, Orphan nuclear receptor PXR, PAR 1, PAR 2, PAR, PAR q, PAR1, PAR2, PARq, pregnane X nuclear receptor variant |
Similar products |
NR1I2 |
Available |
|
Swiss-Prot |
O75469 |
Application all |
WB: 1:500ca.1:2000 IHC: 1:50ca.1:200 |
Background |
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. |
Product |
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
NR1I2 pAb detects endogenous levels of NR1I2 protein. |
WB |
Western blot (WB) analysis of NR1I2 polyclonal antibody |
BiowMW |
ca. 50 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
BXR, Nr1i2, NR1I2_HUMAN, Nuclear receptor subfamily 1 group I member 2, ONR 1, ONR1, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PAR1, Orphan nuclear receptor PXR, PAR 1, PAR 2, PAR, PAR q, PAR1, PAR2, PARq, pregnane X nuclear receptor variant 2, Pregnane X receptor, PRR, PXR, SAR, Steroid and xenobiotic receptor, SXR |
Immunogen |
Recombinant full length Human NR1I2. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.