Item no. |
BS70731-50 |
Manufacturer |
Bioworld Technology, Inc
|
Amount |
50ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IF, IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
TIP, ESA1, PLIP, TIP60, cPLA2, HTATIP, ZC2HC5, HTATIP1, |
Available |
|
Buffer composition |
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Background |
The MOZ gene was initially isolated as a consequence of two variant translocations that were identified in a distinct subtype of acute myeloid leukemias and resulted in the formation of MOZ fusion proteins. These fusions involve the HAT domain of MOZ with the activation domain of either transcriptional co-activator protein TIF2/GRIP1 or CBP, and lead to enhanced transcriptional activation by a mechanism involving aberrant histone acetylation. Additional MOZ-related proteins, including MORF (MOZrelated factor) and TIP60 (TAT-interacting proteins 60), share significant similarities with MOZ including the putuative HAT domain. TIP60 was originally identified as a co-activator for the HIV TAT protein and also functions as a nuclear hormone receptor co-activator that enhances ligand dependent steroid receptor-mediated transactivation involving the androgen, estrogen and progesterone receptors. |
Application info |
WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
Swiss-Prot |
Q92993 |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
KAT5 polyclonal antibody detects endogenous levels of KAT5 protein. |
BiowMW |
ca. 58 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
TIP, ESA1, PLIP, TIP60, cPLA2, HTATIP, ZC2HC5, HTATIP1, |
Immunogen |
Recombinant protein of human KAT5. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.