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BCHE polyclonal antibody

BCHE polyclonal antibody

Manufacturer	Bioworld Technology, Inc
Category	Neuroscience Molecular Targets for Neuroscience Antibodies Western Blot Immunofluorescence Primary Antibodies
Type	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Applications	WB, IF
Amount	100ul
Host	Rabbit
Item no.	BS6965-100
Targets	BCHE
eClass 6.1	32160702
eClass 9.0	32160702
Available
Alias	Cholinesterase, Acylcholine acylhydrolase, Butyrylcholine esterase, Choline esterase II, Pseudocholinesterase, BCHE, CHE1, Butyrylcholinesterase
Swiss-Prot	P06276
Application all	WB: 1:500ca.1:2000
Background	Present in most cells except erythrocytes, butyrylcholine esterase (BChE), also designated acylcholine acylhydrolase or pseudocholinesterase, has esterase activity as well as aryl acylamidase activity. It hydrolyzes acylcholine into choline and carboxylate. BChE is synthesized in the liver and is highly reactive with organophosphate esters. BChE can form a homotetramer composed of two dimers linked by a disulfide bond. Defects in the gene encoding BChE are associated with the disease hypocholinesterasemia. Inhibition of BChE effects the toxicity of organophosphates in the respiratory system suggesting that BChE may play a role in respiratory function. In addition, BChE may play an important pharmocological role by hydrolyzing toxic esters. This suggests an involvement of BChE in a treatment for intoxication with substances such as cocaine.
Product	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Purification and Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	BCHE pAb detects endogenous levels of Cholinesterase protein.
WB	Western blot analysis of extracts of various cell lines, using BCHE pAb.
IHC	Immunohistochemistry (IHC) analysis of BCHE polyclonal antibody in paraffin-embedded Rat Kidney tissue.
IF	Immunofluorescence analysis of U2OS cells, using BCHE polyclonal antibody
BiowMW	ca. 68 kDa
Note	For research use only, not for use in diagnostic procedure.
Alternative Name	Cholinesterase, Acylcholine acylhydrolase, Butyrylcholine esterase, Choline esterase II, Pseudocholinesterase, BCHE, CHE1, Butyrylcholinesterase
Immunogen	Recombinant full length Human BCHE.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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