Fibrinogen beta / FGB polyclonal antibody

P02675

Fibrinogen is important in platelet aggregation, the final step of the coagulation cascade (i.e., the formation of Fibrin) and determination of plasma viscosity and erythrocyte aggregation. It is both constitutively expressed and inducible during an acute phase reaction. Hemostasis following tissue injury deploys essential plasma procoagulants (Prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade leading to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Following vascular injury, Fibrinogen is cleaved by Thrombin to form Fibrin, which is the most abundant component of blood clots. The cleavage products of Fibrinogen regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

FGB pAb detects endogenous levels of FGB protein.

Immunohistochemistry (IHC) analysis of Fibrinogen beta / FGB polyclonal antibody in paraffin-embedded Rat Kidney tissue.

For research use only, not for use in diagnostic procedure.

Recombinant full length Human Fibrinogen beta.