Item no. |
BS6435-50 |
Manufacturer |
Bioworld Technology, Inc
|
Amount |
50ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
BMP and activin membrane-bound inhibitor homolog, Non-metastatic gene A protein, Putative transmembrane protein NMA, BAMBI, NMA |
Similar products |
BAMBI |
Available |
|
Swiss-Prot |
Q13145 |
Application all |
WB: 1:500ca.1:2000 IHC: 1:50ca.1:200 |
Background |
BAMBI (BMP and activin membrane-bound inhibitor homolog, NMA), also designated Non-metastatic gene A protein, is a membrane spanning glycoprotein that acts as a negative regulator of TGF-beta signaling during development. The BAMBI family of proteins are related to type I TGF-beta receptor family, however, BAMBI is a pseudoreceptor that lacks an intracellular serine/threonine kinase domain. BAMBI transcription regulation is under the influence of beta-catenin, BMP, smad3 and smad4. BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues. BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines. |
Product |
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
BAMBI polyclonal antibody detects endogenous levels of BAMBI protein. |
BiowMW |
ca. 29 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
BMP and activin membrane-bound inhibitor homolog, Non-metastatic gene A protein, Putative transmembrane protein NMA, BAMBI, NMA |
Immunogen |
Recombinant full length Human BAMBI. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.