Item no. |
BS61326-100 |
Manufacturer |
Bioworld Technology, Inc
|
Amount |
100ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Tryptase gamma (EC:3.4.21.-), Serine protease 31, Transmembrane tryptase, Tryptase gamma light chain, Tryptase gamma heavy chain, TPSG1, PRSS31, TMT |
Similar products |
TPSG1 |
Available |
|
Swiss-Prot |
Q9NRR2 |
Application all |
WB: 1:500ca.1:1000 |
Background |
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. |
Product |
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.8. |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -25C long term. Avoid freeze-thaw cycles. |
Specificity |
TPSG1 pAb detects endogenous levels of TPSG1 protein. |
WB |
Western blot (WB) analysis of TPSG1 pAb at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:RAW264.7 whole cell lysate Lane3:PC12 whole cell lysate |
BiowMW |
ca. 34 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
Tryptase gamma (EC:3.4.21.-), Serine protease 31, Transmembrane tryptase, Tryptase gamma light chain, Tryptase gamma heavy chain, TPSG1, PRSS31, TMT |
Immunogen |
A synthetic peptide corresponding to residues in Human TPSG1. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.