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SH2D1A polyclonal antibody

SH2D1A polyclonal antibody

Item no.	BS60496-100
Manufacturer	Bioworld Technology, Inc
Amount	100 ul
Quantity options	100 ul 50 ul
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Glucose Homeostasis Aging & Neurological Disorders Antibodies Obesity Western Blot Primary Antibodies By Organ Breast Cancer
Type	Antibody Polyclonal
Applications	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Conjugate/Tag	Unconjugated
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	SH2 domain-containing protein 1AAlternative name(s):Duncan disease SH2-proteinSignaling lymphocytic activation molecule-associated proteinShort name:SLAM-associated proteinT-cell signal transduction molecule SAPGene namesi Name:SH2D1A, DSHP, SAP
Similar products	SH2D1A
Available
Application Notes	WB: 1:500~1:1000
Background	SH2D1A, also SH2 domain protein 1A, SAP and CD150/SLAM (signaling lymphocyte activation molecule)-associated protein, influences signaling pathways involving SLAM molecules at the interface between T and B cells. SH2D1A modulates SLAM by blocking the recruitment of tyrosine phosphatase SHP2 to the phosphorylated cytoplasmic domain of SLAM. SLAM activation mediates expansion of activated T cells during immune responses, induces production of interferon-© and changes the functional profile of subsets of T cells. SH2D1A is a hydrophilic, 128 amino acid protein that is 96% homologous to the mouse protein in both SH2 and tail domains. SH2D1A is present in all major subsets of T cells, including CD4+, CD45RO+, CD45RA+ and CD8+, but not in B cells. SH2D1A can interact via an SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of cell-surface receptors SLAM (CD150), CD84, CD229 (LY9) and CD244 (2B4).
Manufacturer - Product	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Manufacturer - Specificity	SH2D1A polyclonal antibody detects endogenous levels of SH2D1A protein.
Molecular Weight	~ 14 kDa
Note	For research use only, not for use in diagnostic procedure.
Immunogen	A synthetic peptide corresponding to residues in Human SH2D1A.
Modification	Unmodification

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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