Comparison

RPA1 polyclonal antibody

Item no. BS60446-100
Manufacturer Bioworld Technology, Inc
Amount 100 ul
Quantity options 100 ul 50 ul
Category
Type Antibody Polyclonal
Applications WB
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Conjugate/Tag Unconjugated
Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Replication protein A 70 kDa DNA-binding subunit, RP-A p70, Replication factor A protein 1, Short name=RF-A protein 1, Single-stranded DNA-binding protein, Cleaved into the following chain:Replication protein A 70 kDa DNA-binding subunit, N-terminally processed, RPA1, REPA1, RPA70
Similar products RPA1
Available
Application Notes
WB: 1:500~1:1000
Background
The single-stranded-DNA-binding proteins (SSBs) are essential for DNA function in prokaryotic and eukaryotic cells, mitochondria, phages and viruses. Replication protein A (RPA), a highly conserved eukaryotic protein, is a hetero-trimeric SSB. RPA plays an important role in DNA replication, recombination and repair. The binding of human RPA (hRPA) to DNA involves molecular polarity in which initial hRPA binding occurs on the 5' side of an ssDNA substrate and then extends in the 3' direction to create a stably bound hRPA. RPA is a major damage-recognition protein involved in the early stages of nucleotide excision repair. It can also play a role in telomere maintenance. The RPA 70 kDa subunit binds to ssDNA and mediates interactions with many cellular and viral proteins. The DNA binding domain lies in the middle of RPA 70 kDa subunit and comprises two structurally homologous subdomains oriented in tandem. RPA contains a conserved four cysteine-type zinc-finger motif, which mediates the transition of RPA-ssDNA interaction to a stable RPA-ssDNA complex in a redox-dependent manner.
Manufacturer - Product
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Manufacturer - Specificity
RPA1 polyclonal antibody detects endogenous levels of RPA1 protein.
Molecular Weight
~ 195 kDa
Note
For research use only, not for use in diagnostic procedure.
Immunogen
A synthetic peptide corresponding to residues in Human RPA1.
Modification
Unmodification

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ul
Available: In stock
available

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question

Submit a bulk request

Questions about this Product?
 
Close