C4A/C4B polyclonal antibody

P0C0L4/P0C0L5

The complementcomponent proteins C3, C4 and C5 are potent anaphylatoxins that are released during complement activation, a system of ligand-surface protein interactionsspecificto cells of hematopoieticlineage. These proteins belong to thealpha2-macroglobulin family, but retain distinctive featuresincluding an anaphylatoxin domain and a netrin (NTR) domain. The human C4 gene is polymorphic at two loci, C4A and C4B, mapping to chromosome 6p21.32. C4A expressesthe Rodgers(Rg) blood group Ag, while C4B expressesthe Chido(Ch) blood group Ag. C4 is expressed as a precursor that iscleaved into alpha, beta and gamma chains, all ofwhich are non-identicalcleavage products. Thealphachain of C4may be cleaved to produce an acidicisotype, C4a, which reactswith amino groups, and a basicisotype, C4b, which reactswith hydroxyl groups. Deficiency in the C4 gene is associatedwith autoimmune or immune complex disorders, such assystemiclupus erythematosus.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

C4A/C4B pAb detects endogenous levels of C4A and C4B protein.

ca. 193 kDa

Complement C4-A, Acidic complement C4 C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, Complement C4 beta chain, Complement C4-A alpha chain, C4a anaphylatoxin, C4b-A, C4d-A, Complement C4 gamma chain, C4A, CO4, CPAMD2