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PRPF18 polyclonal antibody

PRPF18 polyclonal antibody

Manufacturer	Bioworld Technology, Inc
Category	Metabolism Diabetes Antibodies Western Blot Immunocytochemistry Primary Antibodies
Type	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Applications	WB, ICC
Amount	50ul
Host	Rabbit
Item no.	BS5866-50
eClass 6.1	32160702
eClass 9.0	32160702
Available
Alias	Pre-mRNA-splicing factor 18, PRP18 homolog, hPRP18, PRP18, HPRP18
Swiss-Prot	Q99633
Application all	WB: 1:500ca.1:1000 ICC: 1:50ca.1:200
Background	PRPF18 (pre-mRNA-splicing factor 18), also known as HPRP18, is a 342 amino acid protein that localizes to nuclear speckles and plays a role in the second step of pre-mRNA splicing. A member of the PRP18 family, PRPF18 contains seven WD repeats and exists as two alternatively spliced isoforms which are encoded by a gene located on human chromosome 10p13. Chromosome 10 contains over 800 genes and 135 million nucleotides. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. Other chromosome 10 associated disorders include Cockayne syndrome, tetrahydrobiopterin deficiency and trisomy 10.
Product	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Purification and Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	PRPF18 pAb detects endogenous levels of PRPF18 protein.
WB	Western blot (WB) analysis of PRPF18 pAb at 1:500 dilution Lane1:HEK29T cell lysate Lane2:sp2/0 cell lysate Lane3:H9C2 cell lysate
BiowMW	ca. 40 kDa
Note	For research use only, not for use in diagnostic procedure.
Alternative Name	Pre-mRNA-splicing factor 18, PRP18 homolog, hPRP18, PRP18, HPRP18
Immunogen	Synthetic peptide, corresponding to amino acids 223-268 of Human PRPF18.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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