Comparison

HDAC2 (phospho-S394) polyclonal antibody

Item no. BS4637-100
Manufacturer Bioworld Technology, Inc
Amount 100 ul
Quantity options 100 ul 50 ul
Category
Type Antibody Polyclonal
Applications WB
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Conjugate/Tag Unconjugated
Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Histone deacetylase 2, HD2, Name: HDAC 2
Similar products HDAC2
Available
Application Notes
WB: 1:500~1:1000
Background
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (for p300/CBP-associated factor), p300/CBP and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated mammalian RPD3) and HDAC3, all of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases.
Manufacturer - Product
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Manufacturer - Specificity
p-HDAC2 (S394) polyclonal antibody detects endogenous levels of HDAC2 protein only when phosphorylated at Ser394.
Molecular Weight
~ 60 kDa
Note
For research use only, not for use in diagnostic procedure.
Pathway
Notch Signaling, Nuclear Receptor Signaling, Cell Cycle Control G1 S Checkpoint, DNA Methylation, Epigenetic Writers and Erasers of Histone H3, Epigenetic Writers and Erasers of Histones H2A H2B and H4
Immunogen
Synthetic phosphopeptide derived from human HDAC2 around the phosphorylation site of Serine 394.
Modification
Phosphorylation

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ul
Available: In stock
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