Item no. |
BS4339-50 |
Manufacturer |
Bioworld Technology, Inc
|
Amount |
50 ul |
Quantity options |
100 ul
50 ul
|
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IHC |
Specific against |
Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus) |
Host |
Rabbit |
Conjugate/Tag |
Unconjugated |
Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Ribosomal protein S6 kinase I, S6K, S6K1, 70 kDa ribosomal protein S6 kinase 1, p70 S6 kinase alpha, p70 S6K, p70-S6K, P70S6K, p70 S6 kinase α, Name: RPS6KB1, STK14A, p80 S6K1, p85 S6 kinase, p85 S6K, p85S6K |
Similar products |
p70 S6K |
Available |
|
Application Notes |
WB: 1:500~1:1000
IHC: 1:50~1:200 |
Background |
p70 S6 kinase is a mitogen activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression.Phosphorylation of Thr229 in the catalytic domain and Thr389 in the linker domain are most critical for kinase function. Phosphorylation of Thr389, however, most closely correlates with p70 kinase activity in vivo. Prior phosphorylation of Thr389 is required for the action of phosphoinositide 3-dependent protein kinase 1 (PDK1) on Thr229. Phosphorylation of this site is stimulated by growth factors such as insulin, EGF and FGF, as well as by serum and some G-protein-coupled receptor ligands, and is blocked by wortmannin, LY294002 (PI-3K inhibitor) and rapamycin (FRAP/mTOR inhibitor). |
Manufacturer - Product |
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
Manufacturer - Specificity |
p-p70 S6K (T229) polyclonal antibody detects endogenous levels of p70 S6 kinase only when phosphorylated at Thr229. This antibody also detects p85 S6 kinase when phosphorylated at Thr252. |
Molecular Weight |
~ 59, 70, 85 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Pathway |
PI3K AKT signaling, Protein Kinase C Signaling, Hypoxia Signaling, Translational Contral elF4 and p70 S6 Kinase, Inhibition of Apoptosis, Insulin &Glucose Signaling, Mitochondrial Control of Apoptosis, MTOR signaling, ErbB HER Signaling |
Immunogen |
Synthetic phosphopeptide derived from human p70 S6K around the phosphorylation site of Threonine 229. |
Modification |
Phosphorylation |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.