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p70 S6K (phospho-T229) polyclonal antibody

p70 S6K (phospho-T229) polyclonal antibody

Item no.	BS4339-100
Manufacturer	Bioworld Technology, Inc
Amount	100 ul
Quantity options	100 ul 50 ul
Category	Oncology Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Immunohistochemistry Western Blot Cardiovascular Research Myocardial Infarction Primary Antibodies Astrocytoma By Organ Breast Cancer
Type	Antibody Polyclonal
Applications	WB, IHC
Specific against	Human, Mouse, Rat
Host	Rabbit
Conjugate/Tag	Unconjugated
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Ribosomal protein S6 kinase I, S6K, S6K1, 70 kDa ribosomal protein S6 kinase 1, p70 S6 kinase alpha, p70 S6K, p70-S6K, P70S6K, p70 S6 kinase α, Name: RPS6KB1, STK14A, p80 S6K1, p85 S6 kinase, p85 S6K, p85S6K
Similar products	p70 S6K
Available
Application Notes	WB: 1:500~1:1000 IHC: 1:50~1:200
Background	p70 S6 kinase is a mitogen activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression.Phosphorylation of Thr229 in the catalytic domain and Thr389 in the linker domain are most critical for kinase function. Phosphorylation of Thr389, however, most closely correlates with p70 kinase activity in vivo. Prior phosphorylation of Thr389 is required for the action of phosphoinositide 3-dependent protein kinase 1 (PDK1) on Thr229. Phosphorylation of this site is stimulated by growth factors such as insulin, EGF and FGF, as well as by serum and some G-protein-coupled receptor ligands, and is blocked by wortmannin, LY294002 (PI-3K inhibitor) and rapamycin (FRAP/mTOR inhibitor).
Manufacturer - Product	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Manufacturer - Specificity	p-p70 S6K (T229) polyclonal antibody detects endogenous levels of p70 S6 kinase only when phosphorylated at Thr229. This antibody also detects p85 S6 kinase when phosphorylated at Thr252.
Molecular Weight	~ 59, 70, 85 kDa
Note	For research use only, not for use in diagnostic procedure.
Pathway	PI3K AKT signaling, Protein Kinase C Signaling, Hypoxia Signaling, Translational Contral elF4 and p70 S6 Kinase, Inhibition of Apoptosis, Insulin &Glucose Signaling, Mitochondrial Control of Apoptosis, MTOR signaling, ErbB HER Signaling
Immunogen	Synthetic phosphopeptide derived from human p70 S6K around the phosphorylation site of Threonine 229.
Modification	Phosphorylation

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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