Item no. |
BS4210-100 |
Manufacturer |
Bioworld Technology, Inc
|
Amount |
100 ul |
Quantity options |
100 ul
50 ul
|
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IHC |
Specific against |
Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus) |
Host |
Rabbit |
Conjugate/Tag |
Unconjugated |
Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Acetyl-CoA carboxylase 1, Short name=ACC1, ACC-alpha, Biotin carboxylase, ACACA, ACAC, ACC1, ACCA |
Similar products |
ACCalpha |
Available |
|
Application Notes |
WB: 1:500~1:1000 IHC: 1:50~1:200 |
Background |
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the ratelimiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl- CoA carboxylase in human muscle. ACCα (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACCβ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACCα is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted Serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the short-term regulatory mechanism of the enzyme. The gene encoding ACCα, which maps to human chromosome 17, encodes the 265 kDa α form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACCβ is homologous to that of ACCα except for an additional peptide of about 150 amino acids at the N-terminus. |
Manufacturer - Product |
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
Manufacturer - Specificity |
p-ACCα (S80) polyclonal antibody etects endogenous levels of ACCα protein only when phosphorylated at Ser80. |
Molecular Weight |
~ 265 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Immunogen |
Synthetic phosphopeptide derived from human ACCα around the phosphorylation site of Serine 80. |
Modification |
Phosphorylation |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.