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p70 S6K (F428) polyclonal antibody

p70 S6K (F428) polyclonal antibody

Item no.	BS3633-50
Manufacturer	Bioworld Technology, Inc
Amount	50 ul
Quantity options	100 ul 50 ul
Category	Oncology Metabolism Cholesterol & Lipid Metabolism Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Immunohistochemistry Western Blot Immunofluorescence Cardiovascular Research Myocardial Infarction Primary Antibodies Astrocytoma By Organ Breast Cancer
Type	Antibody Polyclonal
Applications	WB, IF, IHC
Specific against	Human, Mouse, Rat
Host	Rabbit
Conjugate/Tag	Unconjugated
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Ribosomal protein S6 kinase I, S6K, S6K1, 70 kDa ribosomal protein S6 kinase 1, p70 S6 kinase alpha, p70 S6K, p70-S6K, P70S6K, p70 S6 kinase α, Name: RPS6KB1, STK14A, p80 S6K1, p85 S6 kinase, p85 S6K, p85S6K
Similar products	p70 S6K
Available
Application Notes	WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Background	p70 S6 kinase is a mitogen activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression. p70 S6 kinase phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs. A second isoform, p85 S6 kinase, is derived from the same gene and is identical to p70 S6 kinase except for 23 extra residues at the amino terminus, which encode a nuclear localizing signal. Both isoforms lie on a mitogen activated signaling pathway downstream of phosphoinositide-3 kinase (PI-3K) and the target of rapamycin, FRAP/mTOR, a pathway distinct from the Ras/MAP kinase cascade. The activity of p70 S6 kinase is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains.
Manufacturer - Product	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Manufacturer - Specificity	p70 S6K (F428) polyclonal antibody detects endogenous levels of p70 S6 Kinase protein.This antibody also recognizes p85 S6 kinase protein.
Molecular Weight	~ 70 kDa
Note	For research use only, not for use in diagnostic procedure.
Pathway	PI3K AKT signaling, Protein Kinase C Signaling, Hypoxia Signaling, Translational Contral elF4 and p70 S6 Kinase, Inhibition of Apoptosis, Insulin &Glucose Signaling, MAPK Erk in Growth and Differentiation Pathway, Mitochondrial Control of Apoptosis, MTOR signaling, ErbB HER Signaling
Immunogen	Synthetic peptide, corresponding to amino acids 400-450 of Human p70 S6K.
Modification	Unmodified

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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