Manufacturer |
Bioworld Technology, Inc
|
Category |
|
Type |
Antibody Polyclonal |
Specific against |
Human, Mouse, Rat |
Applications |
WB, IF, IHC |
Amount |
50ul |
Host |
Rabbit |
Item no. |
BS2994-50 |
Targets |
SDC1;;SDC4 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Alias |
SDC4, AMPHIGLYCAN, MGC22217, SYND4 |
Swiss-Prot |
P31431 |
Application all |
WB: 1:500ca.1:1000 IHC: 1:50ca.1:200 IF: 1:50ca.1:200 |
Background |
Syndecans are type I integral membrane proteoglycans that contain both chondroitin sulfate and heparan sulfate groups. Syndecans are involved in cell-extracellular matrix adhesion and growth factor binding. Syndecan-1 (SYND1, also called CD138) is an 85-92 kDa extracellular matrix receptor, which binds to Collagens, Fibronectin and Thrombospondin. Syndecan-1 and Syndecan-3 (also designated N-Syndecan) interact with MK (midkine), a growth/differentiation factor invloved in embryogenesis of the central nervous system. Syndecan-2 (also designated Fibroglycan) is highly expressed at areas of high morphogenetic activity, such as epithelial-mesenchymal interfaces and the prechondrogenic and preosteogenic mesenchymal condensations. Syndecan-4 (also designated Amphiglycan or Ryudocan) functions cooperatively with integrins in the processes of cell spreading, focal adhesion assembly and actin stress fiber assembly. |
Product |
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
Syndecan-4 (K175) pAb detects endogenous levels of Syndecan-4 protein. |
IHC |
Immunohistochemistry (IHC) analyzes of Syndecan-4 (K175) pAb in paraffin-embedded human brain tissue . |
BiowMW |
ca. 22 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
SDC4, AMPHIGLYCAN, MGC22217, SYND4 |
Immunogen |
Synthetic peptide, corresponding to amino acids 150-198 of Human Syndecan-4. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.