Item no. |
BS2534-100 |
Manufacturer |
Bioworld Technology, Inc
|
Amount |
100ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IF, IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Mucosa-associated lymphoid tissue lymphoma translocation protein 1, MALT lymphoma-associated translocation, Paracaspase, MALT1, MLT |
Similar products |
MALT1 |
Available |
|
Swiss-Prot |
Q9UDY8 |
Application all |
WB: 1:500ca.1:1000 IHC: 1:50ca.1:200 IF: 1:50ca.1:200 |
Background |
Mucosa Associated Lymphoid Tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B-cell lymphomas. MALT1 encodes two Iglike C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11, 18)(q21, q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. The MALT1-API2 fusion protein activates NF-kappaB and creates a signaling pathway, which is influenced by this Bcl10-MALT1 complex. MALT1 mRNA is found in pre-B cells, mature B cells, and plasma cells. |
Product |
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
MALT1 (N324) pAb detects endogenous levels of MALT1 protein. |
WB |
Western blot (WB) analysis of MALT1 (N324) pAb at 1:500 dilution Lane1:HepG2 cell lysate Lane2:SP2/0 cell lysate Lane3:Rat kidney tissue lysate |
BiowMW |
ca. 92 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
Mucosa-associated lymphoid tissue lymphoma translocation protein 1, MALT lymphoma-associated translocation, Paracaspase, MALT1, MLT |
Immunogen |
Synthetic peptide, corresponding to amino acids 295-340 of Human MALT1. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.