N-Cadherin (W745) polyclonal antibody

P19022

Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2-terminal repeats. The most distal of these cadherins is thought to be responsible for binding specificity, transmembrane domains and carboxyterminal intracellular domains. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as beta-catenin, to regulate cadherin function. Members of this family of adhesion proteins include rat cadherin K (and its human homolog, cadherin-6), R-cadherin, B-cadherin, E/P-cadherin and cadherin-5.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

N-cadherin (W745) pAb detects endogenous levels of N-cadherin protein.

Immunohistochemistry (IHC) analyzes of N-cadherin (W745) pAb in paraffin-embedded human brain tissue.

For research use only, not for use in diagnostic procedure.

Synthetic peptide, corresponding to amino acids 710-760 of Human N-Cadherin.