Integrin beta3 (T767) polyclonal antibody

P05106

Integrins are heterodimers composed of noncovalently associated transmembrane alpha and beta subunits. The 16alpha and 8beta subunits heterodimerize to produce more than 20 different receptors. Most Integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain Integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster Integrins by binding to adjacent Integrin receptors, both receptor clustering and ligand occupancy are necessary for the activation of Integrinmediated responses.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Integrin beta3 (T767) pAb detects endogenous levels of Integrin beta3 protein.

Immunohistochemistry (IHC) analyzes of Integrin beta3 (T767) pAb in paraffin-embedded human skeleta l muscle tissue.

For research use only, not for use in diagnostic procedure.

Synthetic peptide, corresponding to amino acids 741-790 of Human Integrin beta3.