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Smad3 (phospho-S423/S425) Rabbit monoclonal antibody

Smad3 (phospho-S423/S425) Rabbit monoclonal antibody

Item no.	BS9938M-100
Manufacturer	Bioworld Technology, Inc
Amount	100ul
Category	Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Cholesterol & Lipid Metabolism Neurodegeneration Targets for Rodent Neurosciences Antibodies Immunohistochemistry Western Blot Immunofluorescence Immunocytochemistry Primary Antibodies
Type	Antibody Monoclonal
Applications	WB, IF, IHC, ICC
Specific against	Human, Mouse
Host	Rabbit
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Mothers against decapentaplegic homolog 3, MAD homolog 3, Mad3, Mothers against DPP homolog 3, hMAD-3, JV15-2, SMAD family member 3, SMAD 3, Smad3, hSMAD3, SMAD3, MADH3
Available
Buffer composition	Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Background	Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad), have been implicated as downstream effectors of TGFß/BMP signaling. Smad1 (also designated Madr1 or JV4-1) and Smad5 are effectors of BMP2 and BMP4 function, while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFß and activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFß signaling by interfering with TGF?-mediated phosphorylation of other Smad family members.
Application info	WB: 1:1, 000 ICC/IF: 1:50-1:200 IHC: 1:50-1:200
Swiss-Prot	P84022
Purification and Purity	Protein A affinity purified
Storage and Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	This antibody detects endogenous levels of Smad3 only when phosphorylated at Ser423 and/or Ser425.
BiowMW	ca. 55 kDa
Note	For research use only, not for use in diagnostic procedure.
Alternative Name	Mothers against decapentaplegic homolog 3, MAD homolog 3, Mad3, Mothers against DPP homolog 3, hMAD-3, JV15-2, SMAD family member 3, SMAD 3, Smad3, hSMAD3, SMAD3, MADH3
Immunogen	Recombinant antibody.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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