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TIN2 polyclonal antibody

TIN2 polyclonal antibody

Manufacturer	Bioworld Technology, Inc
Category	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Polyclonal
Specific against	Human, Mouse
Applications	WB, IHC
Amount	50ul
Host	Rabbit
Item no.	BS71430-50
eClass 6.1	32160702
eClass 9.0	32160702
Available
Alias	TIN2, DKCA3,
Buffer composition	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background	Mammalian telomeric proteins consist of TRF1 (telomeric repeat binding factor), TRF2, tankyrase, and TIN2, which have no recognized orthologs in the budding yeast, Saccharomyces cerevisiae, and RAP1, which is an ortholog to the yeast telomeric protein scRap1. Like scRap1, mammalian RAP1 regulates telomere elongation. RAP1 interacts with two proteins, Rif1 and Rif2, which contribute to telomere length homeostasis. Unlike scRap1, which binds telomeric DNA directly, RAP1 is recruited to telomeres by TRF2. The functional and structural similarities of scRap1 to mammalian RAP1 suggest that the budding yeast preserved RAP1 at telomeres, but lost the TRF component. The telomeric protein TRF1 requires TIN2 to control telomere length in human cells.
Application info	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Swiss-Prot	Q9BSI4
Purification and Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	TIN2 polyclonal antibody detects endogenous levels of TIN2 protein.
BiowMW	ca. 50 kDa
Note	For research use only, not for use in diagnostic procedure.
Alternative Name	TIN2, DKCA3,
Immunogen	Recombinant protein of human TINF2.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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