CXCR2 polyclonal antibody

P25025

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

CXCR2 pAb detects endogenous levels of CXCR2 protein.

ca.41 kDa

C-X-C chemokine receptor type 2, CD 182, CD182, CD182 antigen, CDw128b, Chemokine (CXC) receptor 2, CMKAR2, CXC-R2, CXCR 2, CXCR-2, CXCR2, CXCR2_HUMAN, GRO/MGSA receptor, High affinity interleukin-8 receptor B, IL 8 receptor type 2, IL 8R B, IL-8 receptor type 2, IL-8R B, IL8 RB, IL8 receptor type 2, IL8R B, IL8R2, IL8RA, Interleukin 8 Receptor B