Item no. |
BM-CAC07329-50ug |
Manufacturer |
Biomatik
|
Amount |
50ug |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IHC, ELISA |
Specific against |
Human, Mouse |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
TEA domain family member 4,Transcription factor 13-like 1,Transcription factor RTEF-1,RTEF1, TCF13L1, TEF3,TEAD4 |
Available |
|
Immunogen |
Recombinant human Transcriptional enhancer factor TEF-3 protein (74-434AA) |
Conjugate |
Unconjugated |
Alternative Names |
TEA domain family member 4, Transcription factor 13-like 1, Transcription factor RTEF-1, RTEF1, TCF13L1, TEF3, TEAD4 |
UniProt ID |
Q15561 |
Purification |
Caprylic Acid Ammonium Sulfate Precipitation Purified |
Storage Instructions |
Aliquot and store at -20C. Minimize freezing and thawing. |
Expiry Date |
1 year |
Shipping Condition |
Blue ice |
Comment |
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. |
Restriction |
For research use only. Not for diagnostic procedures. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.