Item no. |
BM-CAC08068-100ug |
Manufacturer |
Biomatik
|
Amount |
100ug |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IF, IHC, ELISA |
Specific against |
Human |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
B-cell linker protein,B-cell adapter containing a SH2 domain protein,B-cell adapter containing a Src homology 2 domain protein,Cytoplasmic adapter protein,Src homology 2 domain-containing leukocyte protein of 65 kDa,SLP-65,BLNK,BASH,SLP65 |
Available |
|
Immunogen |
Recombinant Human B-cell linker protein (41-337AA) |
Conjugate |
Unconjugated |
Alternative Names |
B-cell linker protein, B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte protein of 65 kDa, SLP-65, BLNK, BASH, SLP65 |
UniProt ID |
Q8WV28 |
Purification |
Protein G purified, >95% |
Storage Instructions |
Aliquot and store at -20C. Minimize freezing and thawing. |
Expiry Date |
1 year |
Shipping Condition |
Blue ice |
Comment |
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. |
Restriction |
For research use only. Not for diagnostic procedures. |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.