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Anti-Human/Mouse CD11b PE-Cyanine5

Anti-Human/Mouse CD11b PE-Cyanine5

Item no.	03221-65-100
Manufacturer	BioGems
Amount	100 ug
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Aging & Neurological Disorders Neural Adhesion Molecules Antibodies Flow Cytometry Primary Antibodies By Organ Skin Cancer Oligodendrocyte Markers
Type	Antibody
Format	PE-Cy5
Applications	FC
Clone	M1/70
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2b Kappa
Conjugate/Tag	PE, Cy5
Citations	Sanchez-Madrid, F., Simon, P., Thompson, S., & Springer, T. A. (1983). Mapping of antigenic and functional epitopes on the alpha-and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1.The Journal of experimental medicine, 158(2), 586-602. Ault, K. A., & Springer, T. A. (1981). Cross-reaction of a rat-anti-mouse phagocyte-specific monoclonal antibody (anti-Mac-1) with human monocytes and natural killer cells. The Journal of Immunology, 126(1), 359-364. Springer, T., Galfre, G., Secher, D. S., & Milstein, C. (1978). Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. European journal of immunology, 8(8), 539-551.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Description	The M1/70 monoclonal antibody specifically reacts with the 170 kDa αM integrin chain of mouse CD11b from the Mac-1 integrin (CD11b/CD18). Mac-1 binds to C3bi, CD54 (ICAM-1), and fibrinogen, and it is expressed by granulocytes, macrophages, NK cells, myeloid-derived dendritic cells, microglia, activated lymphocytes, and mouse B-1 cells. The expression is up-regulated on activated neutrophils at the same time that L-selectin is shed from the cell surface. The M1/70 antibody is used for the detection of monocytes, granulocytes, and a subset of natural killer cells in human peripheral blood. M1/70 blocks C3bi binding and cell adherence, but not cell-mediated lysis and it cross-reacts with human CD11b.
Storage Temperature	4C
Formulation	Phosphate-buffered aqueous solution, ≤ 0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Preperation	The product should be stored undiluted at 4C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Interest	Innate Immunity, Angiogenesis

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 5/22/2025

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