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Anti-Human B7-H4 SAFIRE Purified 100 ug

Anti-Human B7-H4 SAFIRE Purified 100 ug

Item no.	86611-25-100
Manufacturer	BioGems
Amount	100 ug
Category	Oncology Antibodies By Cell Type Carcinoma Flow Cytometry Primary Antibodies
Type	Antibody
Format	SAFIRE Purified
Applications	FC
Clone	H74
Specific against	Human
Host	Mouse
Isotype	IgG1 kappa
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Description	The H74 monoclonal antibody binds to human B7-H4, a newly discovered member of the B7 family involved with the negative regulation of T cell immunity. B7-H4 is a type I membrane glycoprotein also known as B7S1, B7X, and VCTN1. Its role in tumor progression may be to protect precancerous cells from the surveillance of the immune system. Further studies are being conducted to determine the exact B7-H4 ligand. It is reported that the H74 antibody binds to human B7-H4 transfected cells and not peripheral blood cells.
Research Interest	Adaptive Immunity
Preperation	The product should be stored undiluted at 4C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
Formulation	Phosphate-buffered aqueous solution, ph7.2.
References	Choi, I. H., Zhu, G., Sica, G. L., Strome, S. E., Cheville, J. C., Lau, J. S., ... & Chen, L. (2003). Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family. The Journal of Immunology, 171(9), 4650-4654. Sica, G. L., Choi, I. H., Zhu, G., Tamada, K., Wang, S. D., Tamura, H., ... & Chen, L. (2003). B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity, 18(6), 849-861. Yao, Y., Wang, X., Jin, K., Zhu, J., Wang, Y., Xiong, S., ... & Zhou, L. (2008). B7-H4 is preferentially expressed in non-dividing brain tumor cells and in a subset of brain tumor stem-like cells. Journal of neuro-oncology, 89(2), 121-129.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 9/20/2024

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