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Anti-Human CD278 (ICOS) PE 100 tests

Anti-Human CD278 (ICOS) PE 100 tests

Item no.	30811-60-100
Manufacturer	BioGems
Amount	100 tests
Category	Oncology Antibodies By Cell Type Hematology Lymphoma Flow Cytometry Primary Antibodies
Type	Antibody
Format	PE
Applications	FC
Clone	ISA-3
Specific against	Human
Host	Mouse
Isotype	IgG1 kappa
Conjugate/Tag	PE
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Description	The ISA-3 monoclonal antibody specifically reacts with human CD278 or Inducible COStimulatory molecule (ICOS), a 47-60 kDA homodimeric glycoprotein also known as H4, AILIM, and CRP-1. It is expressed on activated T cells and a group of thymocytes and is involved in the proliferation, activation, and cytokine production of T cells. When plate-bound, the ISA-3 antibody induces the production of IL-4, 5, 10 in T cells.
Research Interest	Adaptive Immunity
Preperation	The product should be stored undiluted at 4C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation	Phosphate-buffered aqueous solution, ≤ 0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References	Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., & Kroczek, R. A. (1999). ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature, 402, 21-24. Quiroga, M. F., Pasquinelli, V., Martinez, G. J., Jurado, J. O., Zorrilla, L. C., Musella, R. M., ... & Garcia, V. E. (2006). Inducible costimulator: a modulator of IFN-γ production in human tuberculosis. The Journal of Immunology, 176(10), 5965-5974. Buonfiglio, D., Bragardo, M., Redoglia, V., Vaschetto, R., Bottarel, F., Bonissoni, S., ... & Dianzani, U. (2000). The T cell activation molecule H4 and the CD28-like molecule ICOS are identical. European journal of immunology, 30(12), 3463-3467.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 tests

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Delivery expected until 8/23/2024

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