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Anti-Human CD243 (ABCB1) APC

Anti-Human CD243 (ABCB1) APC

Item no.	25511-80-25
Manufacturer	BioGems
Amount	25 tests
Category	Oncology Antibodies By Cell Type Carcinoma Hematology Leukemia Sarcoma Flow Cytometry Primary Antibodies By Organ Breast Cancer
Type	Antibody
Format	APC
Applications	FC
Clone	UIC2
Specific against	Human
Host	Mouse
Isotype	IgG2a
Conjugate/Tag	APC
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Description	The UIC2 monoclonal antibody specifically reacts with CD243, a 170 kDA transmembrane protein also known as human multidrug resistant-1 (MDR-1) or P-glycoprotein (Pgp). It is an ATP binding cassette (ABC) transport and is expressed on B, T, NK cells to the exclusion of monocytes. CD243 is involved in the process that transports molecules across the cellular membranes and plays a role in multidrug resistance. The UIC2 antibody inhibits CD243 mediated efflux.
Research Interest	Stem Cell Research
Preperation	The product should be stored undiluted at 4C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation	Phosphate-buffered aqueous solution, ≤ 0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References	Mechetner, E. B., & Roninson, I. B. (1992). Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Proceedings of the National Academy of Sciences, 89(13), 5824-5828. Chaudhary, P. M., Mechetner, E. B., & Roninson, I. B. (1992). Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes [see comments]. Blood, 80(11), 2735-2739. Goda, K., Fenyvesi, F., Bacsa, Z., Nagy, H., Marian, T., Megyeri, A., ... & Szaba, G. (2007). Complete inhibition of P-glycoprotein by simultaneous treatment with a distinct class of modulators and the UIC2 monoclonal antibody. Journal of Pharmacology and Experimental Therapeutics, 320(1), 81-88.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25 tests

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Delivery expected until 8/23/2024

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